NTP Research Report Series

Aims & Scope

NTP research reports cover research and literature-analysis activities that do not fall under the scope of existing report series. Long-term NTP toxicology and carcinogenicity studies usually involve exposing laboratory animals (rats and mice) to a substance for a period of two years. These studies are designed and conducted to characterize and evaluate the toxicologic potential, including carcinogenic activity, of selected substances. Substances selected for NTP toxicology and carcinogenesis studies are chosen primarily on the basis of human exposure, level of production, and chemical structure. Substance selection is not an indicator of a substance's carcinogenic potential. The methods, results, and conclusions of these studies are published in NTP's Technical Report (TR) series after undergoing peer review. The interpretive conclusions presented in Technical Reports and Abstracts are based only on the results of these NTP studies. The NTP Toxicity Report Series (TOX) includes reports about short-term studies. These studies usually involve exposing laboratory animals (rats and mice) for 3 months to evaluate the toxicity, but exposure can be any duration less than one year. Substances selected for short-term studies are chosen primarily on the basis of human exposure, level of production, and chemical structure. The selection of a substance is not an indicator of its carcinogenic potential. The report abstracts in the NTP Toxicity Report Series include brief descriptions of the findings, but a link to the full report is listed at the end of each abstract. In some cases, the short-term studies for a particular substance may be reported with longer term studies and not included in the TOX report series. NTP has developed a range of techniques and testing regimens for evaluating the potential of environmental and occupational substances to damage the immune system. These materials may include: Food additives Natural products such as mycotoxins Products used in the pharmaceutical, farming, chemical, or consumer product industries Immunotoxicity tests are designed to evaluate immune function and hypersensitivity. These tests are carried out using rodent models, cultured mammalian cells, and other in vitro methods. Genetically modified model reports evaluate the toxicologic potential, including carcinogenic activity, of selected agents in laboratory animals that have been genetically modified. There are two animal types used: TG.AC: This mouse model has an alteration of specific tumor suppressor genes that have been shown to be associated with induced tumors in rodents and in human malignancies. P53 deficient: This mouse model has an alteration of the p53 tumor suppressor gene, which is critical to cell cycle control and DNA repair. NTP has developed a range of techniques and testing regimes to evaluate the potential of environmental and occupational substances to affect development and damage reproductive systems. Prenatal developmental toxicity studies identify substances that may pose a risk to the developing fetus if pregnant women are exposed. Regulatory agencies use the results of well-conducted animal studies to help set human exposure guidelines. We have also developed methods for evaluating the potential toxic effects of exposure to environmental and occupational substances on the reproductive system. These studies are carried out primarily using rodent models.

Based on the Think.Check.Submit framework by DOAJ, COPE & OASPA. All data from verified open sources.

SJR Quartile by Discipline

Scimago ranks this journal separately in each subject category — its quartile can differ by discipline.

Subject Classification